Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers. On August 21, 2025, Douglas Barry notified the board of directors of Tango Therapeutics, Inc. (the “ Company”) of his resignation as Chief Legal and Compliance Officer and Corporate Secretary of the Company, in each case, effective as of September 12, 2025, to pursue another opportunity. Signature Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. Dated: August 25, 2025 TANGO THERAPEUTICS, INC. By: /s/ Daniella Beckman Name: Daniella Beckman Title: Chief Financial Officer