Item 2.02 Results of Operations and Financial Condition. The information set forth in Item 8.01 under the caption “ Preliminary, Unaudited Financial Information” is incorporated into this Item 2.02 by reference.

Item 8.01 Other Events.

Item 9.01. Financial Statements and Exhibits. (d) Exhibits Exhibit Description No. ──────────────────────────────────────────────────────────────────────────────────────── 99.1 Corporate presentation of Tango Therapeutics, Inc. 104 Cover Page Interactive Data File (embedded within Inline XBRL document) Signature Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. TANGO THERAPEUTICS, INC. Dated: October 23, 2025 By: /s/ Daniella Beckman Name: Daniella Beckman Title: Chief Financial Officer